Author: tremendousblog
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106,036 Americans are waiting for an organ transplant. 17 of them die each day. But what if we could give them pig organs? From the Seventeenth Century to Modern Science The first attempted xenotransplantation, or animal-to-human transplant, was done in 1667. Jean-Baptiste Denys gave sheep’s blood to a 15 year…
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I never show this spreadsheet to anyone. 54 top investors. This is my secret weapon. My money is no greener than anybody else’s. So if I want to invest in the best founders, I need to bring something else to the table. This spreadsheet makes it happen. Meet “The Sheet”…
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+ Angel Investing, Angel Investor, Business, Entrepreneur, Entrepreneurship, Finance, Investing, Money, Silicon Valley, Startups, Tech, VC, Venture Capital+
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What happens when you lower the cost of something? You get more of it. My latest investment, Zeon Systems, is doing that for scientific research. Zeon lets you automate experiments. Just describe the experiment in natural language in a ChatGPT-style text box. Then, the robot arms carry it out! There…
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These are the most hated people in Silicon Valley. But if you’re spending time trashing them, you’re wasting your life. A young techie in San Francisco put up a picture of himself and pals having dinner at a nice restaurant. The caption: “went to a fancy dinner in SF and…
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Figma goes public today. Seed investors were locked up for 12 years. That’s a long time to wait! But here’s why we should be grateful for lockups… Every company goes through hard times. If we were allowed to dump our shares, we probably would! Then, we’d miss out on enormous…
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+ Angel Investing, Business, Entrepreneur, Entrepreneurship, FIG, Figma, Finance, Investing, IPO, Money, NASDAQ, Silicon Valley, Startups, Stock Market, Stocks, Tech, Venture Capital+
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I just watched the first AI movie, Red Panda: Firefox of the Clouds. It was fantastic! And it makes me wonder what’s next… Red Panda is a full hour long film, made entirely with AI. Every element, from the visuals to the music, is synthetic. I spoke with the creator…
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Open source dominates server environments and databases. But will open source win AI? This morning, I investigated which models are most popular among developers… America’s Next Top Model There’s no one place to go to definitively determine which models are most popular among developers. But one strong indicator comes from…
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+ AI, Artificial Intelligence, ChatGPT, DeepSeek, Entrepreneur, LLM, Silicon Valley, Startups, Tech, Technology+
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The startup world has a million metrics. CAC, LTV, ROAS. But here are 3 key metrics many founders aren’t looking at… Burn Multiple How do you know if the money you’re burning is producing any results? You won’t, unless you calculate your burn multiple. Here’s how to do it… Burn…
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+ Business, Entrepreneurship, Finance, Investing, Money, Startup, Startups, Stock Market, Venture Capital+
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Every pre-revenue startup is raising at $30-40 million right now. Making money on these bets will be next to impossible. A year or two ago, a company with little or no revenue might have raised at a $10 million cap. Not anymore. The price is going to be over $30…
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+ Angel Investing, Business, Finance, Investing, Money, Personal finance, Silicon Valley, Startups, Stock Market, Stocks, Tech, VC, Venture Capital+
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At $447,054, median home prices reached another record in June. Americans are priced out. But could technology save the day? This afternoon, I’m meeting with a startup that promises to make building a house way faster and cheaper. But before I do, I wanted to research the current state of…
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Tremendous 