“If I did growth stage, I’d be all over this.” I invest at the earliest stages. But every now and then, I see a late stage startup that makes me salivate. Here are 4 of my favorites…

Loyal — Loyal makes longevity treatments for dogs. Their first drugs are nearing approval. They could extend the lifespan of a dog by several years.

We all love dogs, but the real play here is human longevity. If Loyal’s meds work in dogs, they could be adapted to humans one day.

Dogs and humans have very similar biology. Researchers often use dogs to test treatments for humans.

Loyal’s approach to longevity is the most ingenious one I’ve ever seen. It allows them to get a product into market and see if it works without spending untold years in human testing.

Cofertility — Cofertility lets you freeze your eggs for free. The catch: you have to donate some of them to families struggling to conceive.

“That is the most brilliant idea I’ve ever heard,” I thought to myself when I first read about Cofertility. It’s such a neat solution to two problems at once.

Women who can’t afford to freeze their eggs get the service free. Couples struggling to conceive can get an egg.

People are having kids later and later these days. Egg freezing and IVF are going to be the standard.

When that happens, Cofertility could become a massive company.

Orchid Health — Orchid Health lets you screen embryos for potential health problems. This technology could prevent an incredible amount of human suffering.

So often, people reduce any genetic testing to the same, tired cliche: “Ahhh, designer babies!” But preventing serious illnesses is a wonderful mission, and Orchid is a great opportunity to do that.

In the coming years, every parent-to-be will get a test from Orchid or something like it. And our lives will be better for it.

Cuby — Cuby makes mobile factories that build houses. Bring a Cuby factory to a site and you can pop up a subdivision in no time.

Many startups are making prefab housing and transporting it to the building site. Building new types of structures and transporting them on highways is difficult.

Cuby builds a more traditional house and doesn’t need to transport any giant structures. But it builds more quickly and cheaply than conventional builders.

Cuby is the best shot I know of at solving the housing crisis.

If they can make housing more affordable, they’ll help our country enormously. They’ll also make billions of dollars.

Wrap-Up

All these startups share one thing in common: they’re taking an innovative approach to solving a massive problem.

Extending our lifespan, helping us have the families we want, and helping us afford a home are noble missions. They’re also fantastic business opportunities.

Out of the thousands I’ve looked at, these are the best late stage startups around. If you’re a late stage investor, I urge you to contact all of these companies right away.

Meanwhile, I’m looking for startup like these at the earliest stages. So if you’re taking a clever shot at a huge problem, let me know!

Have a great weekend, everybody!

More on tech:

Are Hackers After Your Brain? — The Rise of CogSec

Where I’m Most Excited About Investing Now

The Top 5 Reasons I Pass On a Startup

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