I just listened to a fascinating discussion with Dr. David Sinclair, PhD, on his lab’s recent success in reversing aging in mouse eyes. Sinclair and his team damaged the optic nerves of mice and then, using Yamanaka factors, reprogrammed the cells to “remember” their youthful vitality and regenerate. The mice could then see! The paper was recently published in the journal Nature.
This has significant potential for treating glaucoma in humans as well as someday reversing aging in general. If cells can be reprogrammed to recover the information they had when they were young, many conditions associated with aging could be reversed.
In this discussion (available as a YouTube video or a podcast), Dr. Sinclair also details some of the key things he does to try to prevent and reverse aging
- Supplements/medication: NMN, resveratrol, oleic acid, metformin
- Exercise, in particular weight training
- Intermittent fasting, about 1.5 meals daily
- Monitoring of biomarkers through regular blood testing. He uses a company called Inside Tracker and advises them. This is something I intend to look into further.
- Wears Apple Watch and Oura Ring to track sleep, heart rate variability, etc. This and blood tests can provide an idea if certain interventions are working.
I read Dr. Sinclair’s amazing book shortly after it came out and started taking NMN on that basis. I do seem more energetic these days, although whether that’s due to NMN is anyone’s guess.
You can also get up-to-the-minute insights on aging research from Dr. Sinclair by going to his website here and signing up for his email list, Lifespan Insider (bottom right of page). I just did and am eagerly awaiting some useful tips!